Generation Victoria (GenV) Solving complex issues affecting children and adults – a whole-of-state cohort with whole-of-campus implications

GenV’s vision is to help solve complex issues affecting today’s children and adults through an entire Australian state becoming a single platform that enhances research speed, capacity and translation. Led from the Melbourne Children’s Campus, the GenV Cohort will be open to the families of all 170,000 Victorian newborns over 2021-2. At its foundation are consent; existing geospatial, clinical and administrative data; biosamples; GenV-specific data; and melding observational and intervention design

Neuro-Oncology: The past, the present and the future

Neuro-Oncology had stagnated for several decades with little to no improvement in patient outcomes despite marked improvements in other areas of paediatric oncology. With the advent of advanced genomics and epigenomics and an explosion in our understanding of disease, we are finally seeing improvements. Dr Hansford will discuss the advances in modern Paediatric Neuro-Oncology and highlight the opportunities, problems and challenges as we push for better cure rates and quality of survivorship into the future for children with brain tumours.

The crying infant – diagnosis and management strategies

All babies cry. What is normal and what is abnormal? Is the crying excessive or is that mother’s perception. What causes the crying – hunger, over handling, “wind”, “colic”, “silent reflux”, allergy?

Patient Reported Outcomes in children’s health services: why should we use them and how can they be embedded in Epic?

Patient Reported Outcomes (PRO) have been used for decades in clinical trials, observational studies, population health surveys, and for estimates of quality of life in economic evaluations. However, the use of PROs as part of routine measurement in clinical settings is relatively new.  In this Grand Round, 3 speakers will discuss the use of PROs in the UK, in mental health at RCH and integrating PROs into the EMR.

Influencing global immunisation policy through research in the Asia-Pacific region

Pneumonia is the commonest cause of childhood death throughout the world, especially in low and middle income countries. The pneumococcal conjugate vaccine (PCV) has been available for 19 years, but there are still many outstanding issues in its use: how do we measure the impact of this vaccine when the causes of pneumonia are many; how do we monitor serotype replacement in the post-PCV era; how do we measure herd protection; and how many doses of the vaccine are really needed for optimal protection?

Genetic epilepsies and precision medicine

This Grand Round, presented by Dr Annapurna Poduri from Boston will explore the role of genetics in epilepsy and the importance of pursuing genetic diagnoses in patients with epilepsy as a step toward refined treatment and precision medicine strategies. Dr Puduri will emphasize the importance of integrating what we know from the clinic into clinically relevant model systems.

A child’s right to know – how far does it extend?

The child’s right to know is usually raised in discussions about whether a child should be given information about their medical condition – what it is, what treatment is proposed, what the outlook is long-term. The standard ethical position and usual clinical practice, is that children should receive developmentally appropriate information. Even on this matter, there are noticeable differences about what information is appropriate at what stage, and what counts as a sound reason to give that information

Human Papilloma Virus, epidemiology and immunization in Victoria and the Pacific: implications for paediatricians

In this Grand Round Yasmin will discuss the evolution of our understanding of HPV and cervical cancers through the lens of a paediatric and adolescent gynaecologist. With the planned transition to later onset of cervical screening at 25 years with HPV DNA testing, she launched The Early-Onset Cervical Cancer Study Group in 2007, examining pre-vaccination virology, and cancer morphology, shedding light on predicted impact of HPV vaccination in those under 25 years.
Professor Fiona Russell and her team undertook cervical cancer epidemiology in Fiji and reviewed the cervical cancer screening program to enable the Fiji Ministry of Health to make an evidence-based decision on the introduction of HPV vaccine into the national immunisation schedule.