A call to action: the second Lancet Commission on adolescent health and wellbeing

Almost 10 years has passed since the first Lancet Commission on Adolescent Health and Wellbeing. Whilst some progress has been made, many areas of need are escaping our efforts, and much more needs to be done to ensure optimal adolescent health and wellbeing. This second Commission brought together 44 commissioners from across the globe and disciplines, including 10 youth commissioners who co-led each workstream.

Surgical management of patients with Hypertrophic Cardiomyopathy

Professor Joseph Dearani from the Mayo Clinic is a world-renowned cardiac surgeon, and expert in management of patients with hypertrophic cardiomyopathy. He has accumulated the world’s largest experience with surgical management of these complex patients, and will discuss the lessons.

Vaccine preventable diseases in 2025: Learning from the past and looking forward

Immunisations are one of the world’s greatest public health interventions, and also one of the areas of medicine increasingly susceptible to misinformation. Independent, evidence-based scientific advice to governments and the community is crucial in informing immunisation policy and appropriate utilisation and uptake of safe and effective vaccines.

Getting your heart dirty: A toolkit for clinicians working with children with severe neurological impairment

Advances in medical care and changes in societal expectations have resulted in different patterns of survival for children and adolescents with severe neurological disability. Increased longevity, new and unseen multi-morbidity, and access to an increasing array of new and often invasive interventions offers significant decision-making challenges to children, parents, and clinicians. Sometimes it is not clear if we are helping or harming.

Maternal tuberculosis and impacts on child health

Around a half of women in tuberculosis-endemic countries are infected with Mycobacterium tuberculosis and over 1.7 million females of reproductive age (15-45 years) fall ill with tuberculosis (TB) each year. Pregnancy is associated with an increased risk of TB disease which has major consequences for maternal health – TB is the major non-obstetric cause of maternal mortality globally – and for the health of their baby.

Bringing innovation into everyday care: Insights from Victoria’s genomics journey

Genomics has moved rapidly from being purely a research tool to being part of routine care in many specialities and health services. Past Grand Round presenters have described how this has enhanced their service – how genomic care may improve patient outcomes, is cost-effective and can be delivered rapidly for acute cases.