Active ingredients for mental health interventions

Earlier this year, Wellcome launched a call for proposals to review “active ingredients” of effective interventions for youth anxiety and depression. Each commissioned team will review the evidence for one active ingredient (additional to the ingredients commissioned in 2020). The active ingredients commissioned this year are diverse and cover a range of approaches, including improving communication in families, developing agency through social action, targeting feelings of grief, and using Omega-3 supplements.

Today, they announce the 2021 Commissioned teams and the Centre for Adolescent Health is very proud to announce and congratulate our two recipient teams. 👏👏👏


Congratulations to Dr Monika Raniti, Prof Susan Sawyer and Prof George Patton. They have been commissioned by Wellcome to synthesise the evidence for the role of school connectedness in youth (14-24 years) anxiety and depression, in partnership with a youth advisory committee with lived experience of anxiety or depression.

Read more about the completed project.



Congratulations to Dr Shilpa Aggarwal, Prof George Patton and Prof Nicola Reavley (from the Melbourne School of Population and Global Health). They have been commissioned to review and synthesise evidence on role of religious and spiritual beliefs in prevention, treatment and coping with difficulties in anxiety and depression in young people. The review will focus on the evidence from low- and middle- income countries and will be guided by lived experience consultants participating as co-researchers in the project.

Read more about the completed project.


Both projects are part of the Wellcome “Active Ingredients” commission which aims to identify the biological, cognitive, relational and societal factors that work to improve mental health for most young people, in most contexts, globally. The project will run from July to December 2021.


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