The Insulin-like Growth Factor (IGF) system plays a fundamental role throughout the life cycle, acting via both endocrine and paracrine mechanisms. Studies by Prof George Werther and the Endocrine Research team at the Melbourne Children’s Campus have shown that IGF is critical in early development, especially in the brain, where a deficiency leads to marked microcephaly, and it is essential in repair of ischaemic injury.
The Australian and New Zealand Fontan Registry has demonstrated that the expectations of survival for children born with the most extreme congenital cardiac conditions are much better than previously thought. The Registry has also shown the burden of complications of the Fontan circulation. We will present you with the avenues to improve the outcomes of this population
Qualitative research has quietly and gradually moved from fringe to mainstream in health research. In this presentation, clinical and health services researchers from across Melbourne Children’s Campus will discuss the ways in which qualitative research can add value to health care research, and describe some of their own qualitative studies. Come along to gain an insight into the research that is happening around you, think about how qualitative research might work in your area of interest, and get up to speed on resources available to support and assist clinicians in performing rigorous qualitative research.
For more than 20 years, the RCH campus has boasted one of the pre-eminent biostatistics groups in Australia, as reflected in a recent international conference that was brought to Melbourne (and the southern/eastern hemisphere!) for the first time in its 39 years by an organising committee led by CEBU biostatisticians.
Research throughout the small African county of The Gambia has provided many important lessons for the future of Global health. This seminar will discuss The contributions made by scientists working in the Gambia to reductions in child mortality, including demonstration of the impact of insecticide treated bednets, Haemophilus influenzae and pneumococcal conjugate vaccines in reducing child morbidity and mortality.
Dr Doug Bryan is a paediatrician who has worked at the Royal Children’s Hospital since 1970. During those 48 years the prognosis and life prospects for children with chronic and complex medical conditions have improved dramatically. This has occurred partly from the discovery of new interventions but also in large part to the development of systems of care that specifically focus on the care and needs of these children and their families.
This presentation will highlight the significant nursing leadership that occurs through research and innovation on our campus and how this leadership reflects the World Health Organisation and the International Council of Nurses’ Nursing Now campaign.
This Grand Round will provide an overview of the current status on the use of antimicrobials in Australia, using a One Health perspective. Professor Thursky will describe the challenges facing prescribers and health care organisations in ensuring the judicious use of antimicrobials, and will showcase some of the research underway by the National Centre for Antimicrobial Stewardship.
Pediatric emergency medicine (PEM) is a newer subspecialty in child health starting in Canada in the 1980’s. To build the evidence base for clinical care, single center randomized controlled trials (RCTs) with small sample sizes were conducted. However, this led to potential of poorly designed and conducted trials with inadequate statistical power, which often were not published (if they gave negative answers). Systematic reviews of RCTs started to improve the situation, along with the establishment of research networks performing large RCTs provided more definitive guidance for the clinician.
A detailed understanding of how an organ develops at the level of the gene, cell and tissue is critical for both accurate modelling of disease, and advances in regenerative medicine.
