Research

Vernon Collins Oration: “The power of paediatrics to address child health inequity within a generation: reality or fantasy?”

There has never been a better time for children in the Australian policy world, with portfolios like health, social services, education, disability and treasury all sounding the importance of children for the nation’s wellbeing and growth. At the same time, almost every child health and developmental metric shows stable or growing inequities –preventable inequalities due to social, geographic or economic circumstances. What would it take to change the trajectory of Australia’s children and is it even possible?

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Early Births in Australia: Potential Implications for Child Health

The gestational age at birth in Australia has slowly but steadily declined over the past 30 years, mainly due to increase in planned births (caesarian sections, inductions of labor). The effects of this decline in gestational age to child health are evident at many levels – intensive care, paediatric care, community, and school.

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2024 Reddihough Symposium – Intellectual Disability: A Potentially Treatable Condition

The application of genomics has greatly increased the diagnosis of specific monogenic causes of intellectual
disability and improved our understanding of the neuronal processes that result in cognitive impairment.
Meanwhile, families are building rare disease communities and seeking disease-specific treatments to change
the trajectory of health and developmental outcomes for their children.

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Type 1 diabetes, Aristotle and the Jesuits – functional outcomes in childhood predicting adult sequelae

Arguably, the most important developmental outcome of childhood and adolescence is to grow a good brain. A stable supply of glucose is sine qua non for optimal brain development. Type 1 diabetes (T1D) is the exemplar chronic condition of childhood that disrupts blood and tissue glucose delivery. Thus, the assessment of cognitive, psychological, functional and morphological brain outcomes in T1D is apposite.

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The revolution in the treatment of genetic skeletal disorders: precision therapy in practice

Over the past 15 years, the treatment of genetic skeletal disorders has evolved from purely symptomatic, to the emergence of several precision therapies that promise to change the health outcomes of children affected by these conditions. We have led this knowledge transformation, enabled and fueled by the genomics revolution. This Grand Round will update the progress on the precision treatment of genetic skeletal disorders that sets a template for the better treatment of many other rare genetic conditions.

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We need to talk about sepsis!

In the emergency setting, sepsis is the primary or differential diagnosis for a substantial proportion of febrile or unwell children. In this Grand Round, we will discuss challenges with early recognition and initial management of sepsis in children. We will discuss RCH efforts to improve the care of children with sepsis, including local, national, and international collaborations.

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Small Translation Grants – One Year Later

In this Grand Round meet the recipients of the inaugural small translation research grants. Launched last year by the Clinical Research Incubator, this funding initiative aimed to empower 10 RCH clinicians who were new to research, including nurses, doctors, and allied health professionals.

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Difficult vaccine targets – RSV and Dengue

Both RSV and Dengue have proved to be difficult vaccine targets.  In both cases vaccine development has taken a very long time, and in both cases some vaccine candidates have led to more severe disease in some individuals. We are currently in the middle of an era of remarkable progress in both fields, but problems remain. 

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