From rotavirus discovery to development of the RV3-BB vaccine to prevent rotavirus disease in babies from birth

The discovery of rotavirus as the most common cause of acute dehydrating diarrhea at the Royal Children’s Hospital and University of Melbourne in 1973 provided hope for prevention of a major cause of death in young children worldwide. Building from this discovery, MCRI researchers have dedicated 5 decades to understanding the rotavirus and to the development and implementation of rotavirus vaccines.

Behaviours of concern: An innovative wraparound approach

Children with developmental disabilities often present to hospital with behaviours of concern, creating complex challenges for emergency departments, inpatient units, and community teams. These behavioural crises can be distressing for patients, families and staff, and can strain hospital resources – yet they also offer powerful opportunities for system change.

Adaptive platform trials for rare disease populations

BANDICOOT is an international adaptive platform trial (APT) designed to identify effective therapies that improve health outcomes for critically ill children receiving a haematopoetic stem cell transplant (HCT). Building
on extensive engagement with patients, their parents, and clinicians, we will launch 3 trial domains focused on exercise, nutritional supplementation, and the gut microbiome

To prevent the unpredictable

Mental health risk assessments have always been a challenge, even for the most experienced clinicians. Risk assessment involves understanding not just the severity of the reported symptoms but the underlying motivations and the psychosocial circumstances. 

NAIDOC Week — The Next Generation: Strength, Vision, and Legacy

This year’s NAIDOC theme is The Next Generation: Strength, Vision, and Legacy. Drawing on these words, Commissioner Meena Singh will discuss her work at the Commission for Children and Young People, the importance of hearing and acting upon the voices of Aboriginal children and young people, and how ensuring their safety, and supporting their growth, means we are investing in our future.

Surgical management of patients with Hypertrophic Cardiomyopathy

Professor Joseph Dearani from the Mayo Clinic is a world-renowned cardiac surgeon, and expert in management of patients with hypertrophic cardiomyopathy. He has accumulated the world’s largest experience with surgical management of these complex patients, and will discuss the lessons.

Vaccine preventable diseases in 2025: Learning from the past and looking forward

Immunisations are one of the world’s greatest public health interventions, and also one of the areas of medicine increasingly susceptible to misinformation. Independent, evidence-based scientific advice to governments and the community is crucial in informing immunisation policy and appropriate utilisation and uptake of safe and effective vaccines.