The past, present, and future of paediatric neuro-oncology – using medulloblastoma as an example
Medulloblastoma is the most common malignant brain tumour of childhood. Despite multidisciplinary therapies offered by neurosurgery, radiation oncology and paediatric oncology through cooperative group clinical trials, there are significant late effects of therapy, including but not limited to neuroendocrine deficits, neurocognitive impairment and second malignant neoplasms