The Bacille Calmette-Guérin (BCG) vaccine, a 100-year-old vaccine usually given to protect against tuberculosis, also has ‘off-target’ effects on the immune system that protect against other infections and allergic diseases.
Our Healthy Trajectories research is done in partnership with consumers, clinicians, and researchers with diverse disciplinary expertise. Our goal is to contribute evidence to rapidly improve the health, wellbeing, and participation of those with child-onset disability and their families. We will only be able to ensure that people with disability can participate as equal members of society if we collaborate effectively across disciplines and sectors: we invite your involvement.
International Women’s Day (IWD) is an annual global campaign, marked on 8th March, which celebrates the social, economic, cultural, and political achievements of women. The day also marks a call to action for accelerating women’s equality. Each year the IWD campaign has a new theme, and in 2023 the theme is #EmbraceEquity. https://www.internationalwomensday.com/theme
The Melbourne Children’s Campus has a strong history of academic surgical excellence. As we make strides towards enhancing surgical collaborations, we aim to create a Surgical Research Program that will encourage and support all interested surgeons and surgical trainees.
Interested in combining research with your clinical work? This Grand Round features clinician scientists from the Department of General Medicine. You will hear about their diverse career pathways and research programs, as well as how they balance research with their clinical work and other commitments.
The primary mitochondrial oxidative phosphorylation disorders are characterized by clinical and genetic heterogeneity, limited treatment options, and poor outcomes. Part of the complexity is because both the nuclear and mitochondrial genomes may be involved. Mitochondrial DNA is maternally inherited. From a reproductive counselling perspective, couples with a family history of mitochondrial DNA disease often have limited reproductive options available to them.
Very large, truly population-representative pregnancy cohorts are rare internationally. Generation Victoria (GenV) is a whole-state cohort targeting all newborns (~150,000) and their parents over 2 full years. Components include (i) families recruited soon after birth, (ii) biospecimens from pregnancy onwards, (iii) extensive data linkage supplemented by (iv) minimal GenV collected data, all enabling (v) many additional integrated research studies, both observational and interventional.
The Melbourne Children’s Campus is a global leader for longitudinal and life course data. Being one of the few centres worldwide with such extensive longitudinal cohort studies, we are positioned to address an array of questions central to early life health and development and its progression throughout the life span.
Victoria’s newborn bloodspot screening (NBS) program commenced in 1966 with screening for phenylketonuria, and from the early 1970’s close to 100% of newborns were being screened. Improvements in analytical and genetic testing technologies saw the successive introduction of screening for congenital hypothyroidism, cystic fibrosis and 22 metabolic conditions. Today, Victoria’s NBS program detects about 80 babies per year with these conditions, preventing life-long debilitating outcomes and even death.
Never in the field of health was so much learned by so many in so few months. This Grand Round will recap the lessons from last year, take stock of where we are in February 2022, describe the complex situation with vaccines, and look to what the year might hold for the pandemic and children in Australia and countries around the world.
