The Sodium valproate poisoning CPG has been updated by the Toxicology Committee and reviewed by interstate reviewers.
The Key points for the CPG are
- Toxicity is dose-dependent and serious symptoms are unlikely with ingestions <400 mg/kg
- Sodium valproate concentrations and an ECG can be helpful in assessment
- Early consideration of transfer to a tertiary centre due to need for intensive care support (eg Enhanced elimination with haemodialysis)