The Non-IgE mediated food allergy CPG is a new CPG developed in conjunction with Allergy specialists, together with the CPG Committee and endorsed by the Paediatric Improvement Collaborative (December 2022). This CPG provides a comprehensive overview of the approach to diagnosis and management of non-IgE-mediated food allergies in children, including Food Protein-Induced Allergic Proctocolitis and Food Protein-Induced Enteropathy (which relate to the condition still commonly known to many clinicians as CMPI), and FPIES. 

CPG key points   

1. Non-IgE-mediated food allergies are delayed immune-mediated reactions to food  
2. Non-IgE-mediated allergies are diagnosed on the basis of clinical history and do not require allergy testing  
3. Treatment is based on elimination of the trigger food(s), there is no need for adrenaline or antihistamines  
4. FPIES can lead to dehydration and shock, and may need acute treatment  

This CPG adds to the suite of guidelines for Food Allergy in children. See also IgE-mediated food allergy