MCRI

Type 1 diabetes, Aristotle and the Jesuits – functional outcomes in childhood predicting adult sequelae

Arguably, the most important developmental outcome of childhood and adolescence is to grow a good brain. A stable supply of glucose is sine qua non for optimal brain development. Type 1 diabetes (T1D) is the exemplar chronic condition of childhood that disrupts blood and tissue glucose delivery. Thus, the assessment of cognitive, psychological, functional and morphological brain outcomes in T1D is apposite.

.

The revolution in the treatment of genetic skeletal disorders: precision therapy in practice

Over the past 15 years, the treatment of genetic skeletal disorders has evolved from purely symptomatic, to the emergence of several precision therapies that promise to change the health outcomes of children affected by these conditions. We have led this knowledge transformation, enabled and fueled by the genomics revolution. This Grand Round will update the progress on the precision treatment of genetic skeletal disorders that sets a template for the better treatment of many other rare genetic conditions.

.

Small Translation Grants – One Year Later

In this Grand Round meet the recipients of the inaugural small translation research grants. Launched last year by the Clinical Research Incubator, this funding initiative aimed to empower 10 RCH clinicians who were new to research, including nurses, doctors, and allied health professionals.

.

Difficult vaccine targets – RSV and Dengue

Both RSV and Dengue have proved to be difficult vaccine targets.  In both cases vaccine development has taken a very long time, and in both cases some vaccine candidates have led to more severe disease in some individuals. We are currently in the middle of an era of remarkable progress in both fields, but problems remain. 

.

reNEW: Transforming lives with stem cell medicine

Scientific advances now allow researchers to identify, isolate and engineer stem cells. reNEW aims to deliver treatment outcomes across the breadth of stem cell medicine – new drugs based on human stem cell models, new tissue therapies, and new cell and gene therapies. We look forward to presenting how stem cell medicine and reNEW are advancing treatments for delivery into the clinic across many currently untreatable diseases.

.

Mentally healthy primary schools: A state-wide initiative to increase the capacity of schools to support children

In recent years there has been increasing policy attention paid to child mental health, at a state and national level, given the marked increase in mental health problems in children. In addition to causing distress for children and families, when mental health difficulties are not addressed in a timely way, they can become entrenched and have serious effects into adult life.

.