BANDICOOT is an international adaptive platform trial (APT) designed to identify effective therapies that improve health outcomes for critically ill children receiving a haematopoetic stem cell transplant (HCT). Building
on extensive engagement with patients, their parents, and clinicians, we will launch 3 trial domains focused on exercise, nutritional supplementation, and the gut microbiome
Almost 10 years has passed since the first Lancet Commission on Adolescent Health and Wellbeing. Whilst some progress has been made, many areas of need are escaping our efforts, and much more needs to be done to ensure optimal adolescent health and wellbeing. This second Commission brought together 44 commissioners from across the globe and disciplines, including 10 youth commissioners who co-led each workstream.
Professor Joseph Dearani from the Mayo Clinic is a world-renowned cardiac surgeon, and expert in management of patients with hypertrophic cardiomyopathy. He has accumulated the world’s largest experience with surgical management of these complex patients, and will discuss the lessons.
Immunisations are one of the world’s greatest public health interventions, and also one of the areas of medicine increasingly susceptible to misinformation. Independent, evidence-based scientific advice to governments and the community is crucial in informing immunisation policy and appropriate utilisation and uptake of safe and effective vaccines.
Genomics has moved rapidly from being purely a research tool to being part of routine care in many specialities and health services. Past Grand Round presenters have described how this has enhanced their service – how genomic care may improve patient outcomes, is cost-effective and can be delivered rapidly for acute cases.
There are real challenges in delivering equitable health care in a community, even when there is policy and service goodwill. This is an issue for health services around the world. For the past ten years BiBBS has been working alongside service partners and families to co-design, implement and evaluate multiple early years interventions that are delivered as a part of usual practice in disadvantaged inner-city areas in the UK.
In the last decade, we have seen genetic therapies leap from the benchtop into the neuromuscular clinic. This process is most dramatically illustrated by spinal muscular atrophy (SMA), which was until recently the most common genetic cause of death in infancy.
In this age of subspecialisation, effective communication and collaboration is key. How do we improve the care of children with head and neck conditions? Head & Neck Surgery is an established subspecialty within Otorhinolaryngology globally. Here at RCH, The University of Melbourne & MCRI, we are navigating the ever-changing complexity and diversity of congenital, acquired and neoplastic head and neck conditions.
Opportunities exist to leverage implementation science and quality improvement science to advance quality care. During this presentation we will compare and contrast implementation science and quality improvement science. We will explore how methods from both fields have been used to improve our understanding of discharge communication practices in emergency departments in Canada.
Genomic medicine is rapidly evolving, yet many clinicians outside of clinical genetics face challenges in integrating these advances into routine practice. In this Grand Round, Associate Professor Catherine Quinlan explores her journey mainstreaming genomics in paediatric nephrology, using real-world data from Australia and Ireland and its implementation at The Royal Children’s Hospital.
