The elephant in the room – type 1 diabetes, adverse brain development and metabolic control
Arguably the pre-eminent developmental task of childhood is to grow a good brain. Glucose is the primary metabolic fuel for the brain- peaking at 140-170 grams per day at around 5 years of age with a constant supply critical for normal cerebral metabolism. Thus it is not surprising that developing brains in early childhood are more susceptible to metabolic insult, particularly those resulting from perturbations in blood glucose levels. Type 1 diabetes (T1DM) is one of the most common chronic diseases of childhood and the condition most likely to cause the greatest fluctuations in blood glucose